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A-1331852

BCL-XL inhibitor

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Catalog No. A16190

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
A-1331852 5mg A16190-5

Regular Price: $120.00

Special Price: $96.00

A-1331852 10mg A16190-10

Regular Price: $200.00

Special Price: $160.00

A-1331852 50mg A16190-50

Regular Price: $800.00

Special Price: $640.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.

A-1331852

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Chemical Information

Catalog Num A16190
Actions Inhibitor
M. Wt 658.82
Formula C38H38N6O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1430844-80-6
Synonyms A 1331852, A1331852
SMILES code CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=CC=CC(=C7C6)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O
Chemical Name 3-(1-(((3r,5r,7r)-adamantan-1-yl)methyl)-5-methyl-1H-pyrazol-4-yl)-6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinic acid

Biological Activity

Description
A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.
Targets
Bcl-xL Bcl-w Bcl-2 Mcl-1
<0.01 nM(Ki)4 nM(Ki)6 nM(Ki)142 nM(Ki)

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