AChR



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Catalog No. Product Name Application Product Information
A11545

Metanicotine

Nicotinic receptor agonist
Metanicotine is a neuronal nicotinic receptor agonist, showing high selectivity for the ??4??2 subtype (Ki=26 nM); > 1,000 fold selectivity than ??7 receptors(Ki= 36000 nM).
A11975

Methoctramine hydrate

-
Methoctramine hydrate is a selective M2 muscarinic receptor antagonist at nM concentrations
A10480 SALE

Irsogladine

-
Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
A11987

Darifenacin

-
Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions.
A10417 SALE

Gallamine triethiodide

-
Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity.
A10476

Ipratropium bromide

-
Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.
A10579

Methscopolamine bromide

-
Methscopolamine bromide is a competitive antimuscarinic agent that blocks the binding of acetylcholine at muscarinic acetylcholine receptors (mAChR M).
A10635 SALE

Neostigmine bromide (Prostigmin)

Acetylcholine esterase inhibitor
Neostigmine bromide is a reversible acetylcholine esterase inhibitor that binds to the anionic binding site of AChE.
A10684 SALE

Oxybutynin

-
Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties.
A13071 SALE

Arecoline

-
Arecoline is a cholinergic alkaloid from seeds of the betel nut palm Areca catechu.
A13539

A-582941

α7 nAChR agonist
A-582941 is a selective AChR a7 partial agonist. It exhibits high affinity for both rat and human a7 receptors (Ki values are 10.8 and 16.7 nM, respectively).
A15086

EVP-6124 (Encenicline)

nAChR Inhibitor
EVP-6124 is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs); shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.
A15087

EVP-6124 hydrochloride

nAChR Inhibitor
EVP-6124 hydrochloride is a novel partial agonist of ??7 neuronal nicotinic acetylcholine receptors (nAChRs). EVP-6124 showed selectivity for ??7 nAChRs and did not activate or inhibit heteromeric ??4??2 nAChRs.
A10180 SALE

Bethanechol chloride

Muscarinic receptor agonist
Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors.
A11712 SALE

Orphenadrine citrate

-
Orphenadrine is known to have the following pharmacology: mACh receptor antagonist (anticholinergic); H1 receptor antagonist (antihistamine); NMDA receptor antagonist; NET blocker (norepinephrine reuptake inhibitor); Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker; HERG potassium channel blocker.
A11706

Tropicamide

-
Tropicamide is an anticholinergic used as a mydriatic.
A10386 SALE

Fesoterodine fumarate (Toviaz)

AChR antagonist
Fesoterodine fumarate is a medicine which is used in urinary urgency, reducing the frequency of passing urine and urge urinary incontinence
A11166 SALE

5-hydroxymethyl tolterodine (PNU 200577)

muscarinic receptor antagonist

5-hydroxymethyl tolterodine is a metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.

A11203 SALE

PNU-120596

Nicotinic (α7) Receptor Modulator
PNU-120596 is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors.
A11233 SALE

PNU 282987

α7 nAChR agonist
PNU 282987 (PNU-282,987)is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors.
A10803

Rocuronium bromide

AchR antagonist
Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia.
A10416 SALE

Galanthamine hydrobromide

-
Galanthamine is an AChE inhibitor with IC50 of 14 nM.
A10147 SALE

Biperiden HCl

-
Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype
A10937 SALE

Tolterodine tartrate (Detrol LA)

muscarinic receptor antagonist
Tolterodine tartrate (Detrol LA) is a muscarinic receptor antagonist which is used for the treatment of urinary incontinence.
A11215 SALE

Solifenacin succinate

muscarinic M3 receptor antagoinst
Solifenacin-succinate is a muscarinic M3 receptor antagoinst, used in treatment of urinary incontinence.
A11290

A-867744

modulator of α7 nAChRs
A-867744 is a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.
A10098

Atropine

AChR antagonist
Atropine is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5.
A10808

SVT-40776 (Tarafenacin)

muscarinic receptor antagonist
SVT-40776 is a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder.
A11719 SALE

Rivastigmine tartrate

ChE inhibitor
Rivastigmine tartrate is a dual cholinesterase inhibitor (ChEI). It inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE).
A14353

Pulegone

Acetylcholinesterases inhibitor
Pulegone is a monoterpene compound found in a number of essential oils. The unit of Product is ml.
A15782

Acotiamide hydrochloride trihydrate

Acetylcholinesterase inhibitor
Acotiamide is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.
A15490

Imidafenacin

M3 receptors inhibitor
Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM).
A15268 SALE

Umeclidinium bromide

Muscarinic receptor antagonist
Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
A15042

Cevimeline hydrochloride hemihydrate

M1 agonist
Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
A13548

PF-3635659

muscarinic M(3) receptor antagonist
PF-3635659 is a potent muscarinic M(3) receptor antagonist.
A13761

(-)-Nicotine ditartrate

-
(-)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine recepto).
A14205

TBPB

M1 mAChR agonist
TBPB is an allosteric M1 mAChR agonist with EC50 value of 89 nM that regulates amyloid processing and produces antipsychotic-like activity in rats.
A15950

GTS-21 (DMBX-A)

nAChR agonist
GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.
A15986

Revefenacin

muscarinic receptor antagonist
Revefenacin is potent and selective muscarinic receptor antagonist in development for the treatment of COPD.
A12641

Glycopyrrolate

muscarinic antagonist
Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic.
A14096

Rivastigmine

Cholinesterase inhibitor
Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase.
A12900 SALE

Flavoxate

-
Flavoxate binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem.
A13653

Benzethonium Chloride

nAChR inhibitor
Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
A16390

Acetylcholine iodide

-
Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
A13639

5-Iodo-A-85380 2HCl

nAChR agonist
5-Iodo-A-85380 2HCl is a highly potent and subtype-selective agonist for the a4b2 and a6b2 nicotinic acetylcholine receptors.
A13688

ABT-418 HCl

nAChR agonist
ABT-418 HCl is a neuronal nicotinic acetylcholine receptor agonist.
A10330 SALE

Donepezil hydrochloride

cholinesterase inhibitor
Donepezil is a centrally acting reversible acetylcholinesterase inhibitor.
A11716 SALE

Adiphenine HCl

AChR inhibitor
Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM, used as an antispasmodic drug
A12681

Methyllycaconitine citrate

-
Methyllycaconitine citrate is a potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM.
A12835

MK7622

cholinesterase inhibitor
N/A

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