Afuresertib HCl

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AKT inhibitor‎

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Catalog No. A13030

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Afuresertib HCl 5mg A13030-5

Regular Price: $100.00

Special Price: $85.00

Afuresertib HCl 10mg A13030-10

Regular Price: $150.00

Special Price: $127.50

Afuresertib HCl 25mg A13030-25

Regular Price: $240.00

Special Price: $204.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Afuresertib HCl

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Chemical Information

Catalog Num A13030
Actions Inhibitor
M. Wt 463.78
Formula C18H18Cl3FN4OS
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1047645-82-8
Synonyms GSK2110183, GSK 2110183
SMILES code CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl
Chemical Name N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride

Biological Activity

Description
Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

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