Apoptosis

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Catalog No.
Product Name
Application
Product Information
Product Citation
  1. MIF antagonist is an inhibitor of the dopachrome tautomerase activity of MIF in vitro (IC50 = 7 M) and in cells (IC50 = 25 M).
  2. APR-246 is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity.
  3. IMPDH inhibitor

    AVN-944 (also known as VX-944) serves as an effective oral inhibitor, specifically targeting and inhibiting IMPDH (inosine monophosphate dehydrogenase). This enzyme plays a crucial role as a rate-limiting factor in the synthesis of guanine nucleotides from scratch. Additionally, AVN-944 acts against the synthesis of RNA in arenaviruses, effectively preventing arenavirus infections. Demonstrating a wide spectrum of anti-cancer properties, AVN-944 is utilized in research related to multiple myeloma (MM) and acute myeloid leukemia (AML).

  4. 25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types
  5. p53 activator

    Tenovin-3 is a sirtuin inhibitor.
  6. DAPK inhibitor

    TC-DAPK6 is a potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 uM ATP).
  7. Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
  8. PKD inhibitor

    CID755673 is a potent PKD inhibitor with IC50s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively.
  9. PKD1 inhibitor

    CID797718 is a structural analog of CID755673 (Adooq Catalog No. A13804). It was a 10-time less potent PKD1 inhibitor with an IC50 value of 7.0 +/-0.8 uM.
  10. PERK inhibitor

    ISRIB (trans-isomer) is a potent and selective small molecule inhibitor of PERK signaling (IC50 ~5 nM) that can potently reverse the effects of eIF2α phosphorylation.
  11. Ret kinase inhibitor

    RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
  12. Ecabet sodium is a widely employed mucoprotective agent for the treatment of gastric ulcers.
  13. MDM2/MDMX inhibitor

    WK23 is an inhibitor based on four aromatic groups and able to efficiently fill the binding pockets of MDM2/MDMX, its median inhibitory concentration (IC50) values to MDM2/MDMX are 1.17 and 36 uM, respectively
  14. Caspase inhibitor

    Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
  15. Mdm2 inhibitor

    YH239-EE is a potent p53-MDM2 antagonist and an apoptosis inducer.
  16. IAP antagonist

    GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity.
  17. MDM2/p53 Inhibitor

    Idasanutlin is a potent and selective p53-MDM2 inhibitor.
  18. Mcl-1 inhibitor

    UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
  19. dual cIAP and XIAP inhibitor

    BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.
  20. Irreversible Cysteine Protease inhibitor

    Z-FA-FMK is an irreversible cysteine protease inhibitor.
  21. PERK inhibitor

    ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.
  22. Caspase-9 Inhibitor

    Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
  23. MDM2 inhibitor

    AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).
  24. Mdm2 inhibitor

    MI-773 is a new small molecule inhibitor of the MDM2-p53 interaction, binds to MDM2 with high affinity (Ki=0.88 nM) and blocks the p53-MDM2 interaction.
  25. anti-oxidative agent

    Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.
  26. osteoblast differentiation inducer

    Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP?\2/p38 and ERK1/2 pathway. Asperosaponin ?? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB.
  27. Stat3 inhibitor & Apoptosis inducer

    Homoharringtonine is a cephalotaxine alkaloid which inhibits the formation of diphenylalanine and acetylphenylalanyl-puromycin in liver ribosomes.
  28. Peimisine and peiminine production by endophytic fungus Fusarium sp. isolated from Fritillaria unibracteata var. wabensis.
  29. Bcl-2 Inhibitor

    Acetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic.
  30. Caspase inhibitor

    Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
  31. Caspase inhibitor

    Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity.
  32. 14-3-3 protein Inhibitor

    Difopein, dimeric version of R18 peptide that binds to 14.3.3 proteins with high affinity.
  33. Caspase-3/7 Inhibitor

    Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
  34. Bcl-2 Inhibitor

    AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM.
  35. Apoptosis inducer

    Episilvestrol is a derivative of Silvestrol, which can induce apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7; 5'myc-UTR-LUC inhibtior (IC50= 0.8 nM).
  36. Necroptosis inhibitor

    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
  37. p53-MDM2 interaction inhibitor

    p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.
  38. p53-MDM2 interaction inhibitor

    p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins.
  39. Tyrosine kinase inhibitor

    Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
  40. Apoptosis inducer

    SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells.
  41. Survivin suppressant

    YM-155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
  42. Fluorogenic caspase substrate

    Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
  43. Caspase-3 inhibitor

    AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM).
  44. Caspase-3 inhibitor

    Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
  45. Caspase-3 activator

    PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols.
  46. Fluorogenic caspase substrate

    Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.
  47. Necroptosis inhibitor

    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
  48. Necroptosis inhibitor

    Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
  49. Apoptosis Inducer

    2,3 DCPE displays anticancer agent properties and induces ERK activation.
  50. Apoptosis Inducer

    CHM 1 is a potent, selective antitumor agent in human hepatocellular carcinoma in vitro.

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