Bromodomain



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Catalog No. Product Name Application Product Information
A12729

(+)-JQ1

BET Inhibitor
(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
A14160

(-)-JQ1

BET bromodomain inhibitor
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes.
A15947

BAZ2-ICR

BAZ2 bromodomain inhibitor
BAZ2-ICR is an excellent chemical probe for functional studies of the BAZ2 bromodomains in vitro and in vivo.
A16068

BI-7273

BRD9 BD Inhibitor
BI-7273 is a selective, and cell-permeable BRD9 BD inhibitor.
A16196

BI-9564

BRD7/9 inhibitor
BI-9564 is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 uM, respectively).
A13163

Bromosporine

bromodomain inhibitor
Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 ??M, 0.29 ??M, 0.122 ??M and 0.017 ??M for BRD2, BRD4, BRD9 and CECR2, respectively.
A16076

CPI 0610

BET bromodomain inhibitor
CPI 0610 is a small molecule inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity.
A13068

CPI-203

BET bromodomain Inhibitor
CPI203 is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~37 nM (BRD4 α-screen assay).
A11783

GSK 1210151A (I-BET151)

BET Bromodomain Inhibitor
GSK1210151A is a novel selective inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3, and BRD4.
A11440

GSK 525762A (I-BET-762)

BET inhibitor
GSK-525762A is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family
A14134

GSK 525768A

BET bromodomain inhibitor
GSK 525768A is the enantiomer compound of GSK 525762A(HY-13032, which is a potent small molecule inhibitor that disrupt the function of the BET family of bromodomains (Brd2, Brd3, and Brd4); GSK 525768A has NO activity towards BET.
A16092

GSK 5959

BRPF1 bromodomain inhibitor
GSK 5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.
A14015

GSK2801

BAZ2A and BAZ2B inhibitor
GSK2801 is a very potent inhibitor of the BAZ2 family of bromodomain containing proteins
A15872

I-BRD9

Selective BRD9 inhibitor
I-BRD9 is a potent and selective BRD9 inhibitor with pIC50 of 7.3, while it displayed a pIC50 of 5.3 against BRD4.
A13165

I-CBP112

CBP/p300 bromodomain inhibitor
I-CBP112 is a highly potent and selective p300/CBP bromodomain inhibitor (IC50 ~0.14-0.17 uM for CBP and ~0.625 uM for p300).
A13749

MS436

BRD4 inhibitor
MS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM.
A13890

OTX015

BET inhibitor
OTX015 is an orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM).
A13451

PF-4

BRPF1 bromodomain inhibitor
PFI-4 is a potent and selective and cell permeable BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4.
A12545

PFI-1

BET inhibitor
PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4.
A13956

RVX-208

BET bromodomain inhibitor
RVX-208 is a potent BET bromodomain inhibitor with IC50 of 0.510 ??M for BD2, about 170-fold selectivity over BD1.
A13227

SGC-CBP30

CBP/p300 bromodomain inhibitor
SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators.
A13717

UNC 669

L3MBTL inhibitor
UNC669 is a small-molecule antagonist of methyl-lysine (KMe) reader protein with selectivity for L3MBTL1 and L3MBTL3 (IC50 of 4.2μM and 3.1μM respectively)
A12948

UNC1215

L3MBTL3 inhibitor
UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity.

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