CaMK

Inhibitory Selectivity
Catalog No.Inhibitor Name CaMKIICaMKIIICaMKKαCaMKKβOther
A14307NH125
****
PKC,PKA
A11473KN-62
**
A14288KN-93 Phosphate
***
A16345STO-609 acetate
***
****
A13804CID 755673
*
PKD1, PKD2, PKD3, PKC, CAK, PLK1, Akt
A13447A-484954
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A11473 SALE

KN-62

CaM kinase II inhibitor
KN-62 is a selective, cell-permeable inhibitor of CaM kinase I.
A16318

CRT-0066101

PKD Inhibitor
CRT-0066101, potent inhibitor of protein kinase D (PKD); inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively).
A13809

CID 797718

PKD1 inhibitor
CID797718 is a structural analog of CID755673 (Adooq Catalog No. A13804). It was a 10-time less potent PKD1 inhibitor with an IC50 value of 7.0 +/-0.8 uM.
A15139

KN-92 phosphate

CaMKII inhibitor
KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
A15138

KN-92 hydrochloride

CaMK-II Inhibitor
KN-92 hydrochloride is a negative control for KN-93.
A15137

KN-92

CaMK-II Inhibitor
KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
A13447

A-484954

eEF2K (CAMKIII) inhibitor
A-484954 is a potent, selective inhibitor of eukaryotic longation factor-2 kinase (eEF2K).
A13897

K252a

CaMK/Phosphorylase inhibitor
K252a is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50 = 1.8 and 1.7 nmol/L, respectively).
A14307

NH125

eEF-2 inhibitor
NH125 is a selective eEF-2 kinase inhibitor.
A14288 SALE

KN-93 Phosphate

CaMKII inhibitor
KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.
A13804 SALE

CID 755673

PKD inhibitor
A13276 SALE

KN-93

CaM kinase II inhibitor
KN-93 is an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase.
A10719 SALE

Phenoxybenzamine hydrochloride

α-adrenergic (AR) antagonist/CaM inhibitor
Phenoxybenzamine is a cell-permeable, non-specific, irreversible α-adrenergic (AR) antagonist that also acts as an CaM inhibitor.
A12423

kb NB 142-70

PKD inhibitor
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively).
A12416

CID 2011756

PKD inhibitor
CID 2011756 is a protein kinase D (PKD) inhibitor (IC50 values are 0.6, 0.7 and 3.2 μM for PKD2, PKD3 and PKD1 respectively).
A16345

STO-609 acetate

CaMKK inhibitor
STO-609 is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKK?? and CaMKK?? (Ki = 80 and 15 ng/ml, respectively).

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