CSF-1R

Inhibitory Selectivity
Catalog No.Inhibitor Name CSF-1ROther
A10025Linifanib
***
VEGFR1/FLT1,FLT3,VEGFR2/KDR
A10679OSI-930
**
FLT1,KDR,LCK
A11959GW2580
*
A13772CEP-32496
***
c-Kit,RET,PDGFRβ
A15520Pexidartinib
**
A15540BLZ945
****
A11472Ki 20227
****
VEGFR-2, PDGFRβ, c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A10025 SALE

Linifanib (ABT-869)

VEGFR/PDGFR inhibitor
Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively.
A10679 SALE

OSI-930

c-Kit/VEGFR Inhibitor
OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.
A11959 SALE

GW2580

CSF-1R inhibitor
GW2580 is a small-molecule, ATP-competitive inhibitor of cFMS kinase.
A13772 SALE

CEP-32496

Raf inhibitor
CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity.
A15540 SALE

BLZ945

CSF1R inhibitor
BLZ945 is a potent and selective CSF-1R kinase inhibitor. It attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas.
A15520 SALE

Pexidartinib (PLX3397)

CSF1/Kit/FLT3 inhibitor
Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
A11518 SALE

Pazopanib (GW-786034)

VEGFR inhibitor
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
A12687 SALE

JNJ-28312141

CSF1R inhibitor
JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.
A11472 SALE

Ki 20227

M-CSFR, CSF1R inhibitor
Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R).

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