Sorafenib (Nexavar)Catalog No. A10001

Quick Overview

Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
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Sorafenib (Nexavar)

Product Information
Catalog Num A10001
M. Wt 637
Formula C21H16ClF3N4O3.C7H8O3S
Solubility DMSO>127mg/mL Water <1mg/mL Ethanol <1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 475207-59-1
Synonyms Bay 43-9006
Chemical Name 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
SMILES Code CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Biological activity
Introduction
Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
Targets
Target Value
Raf-1IC50: 6nM
VEGFR2/Flk1IC50: 15nM
B-RafIC50: 22nM
B-Raf(V599E)IC50: 38nM
PDGFRβIC50: 57nM
mPDGFRβIC50: 57nM
FLT3IC50: 58nM
c-KitIC50: 68nM
VEGFR2IC50: 90nM
FGFR1IC50: 580nM
ERK1IC50: >10μM
MEK1IC50: >10μM
EGFRIC50: >10μM
HER2IC50: >10μM
IGF-1RIC50: >10μM
c-MetIC50: >10μM
PKBIC50: >10μM
PKAIC50: >10μM
CDK1/CyclinBIC50: >10μM
PKCαIC50: >10μM
PKCγIC50: >10μM
Pim1IC50: >10μM
Solubility
Solubility (25C)* In vitro DMSO 63 mg/mL heating (135.53 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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