AT7519Catalog No. A10093

Quick Overview

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.
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AT7519

Product Information
Catalog Num A10093
M. Wt 382.2
Formula C16H17Cl2N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 844442-38-2
Synonyms AT-7519
Chemical Name N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide
SMILES Code C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl

Biological activity
Introduction
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.
Targets
Target Value
CDK9/CyclinTIC50: <10nM
CDK5/p35IC50: 13nM
CDK2/CyclinAIC50: 47nM
GSK-3βIC50: 89nM
CDK4/CyclinD1IC50: 100nM
CDK6/CyclinD3IC50: 170nM
CDK1/CyclinBIC50: 210nM
CDK3/CyclinEIC50: 360nM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
TrkBIC50: >1μM
JAK2IC50: >1μM
CDK7/CyclinH/MAT1IC50: 2.4μM
SAPK2A(p38α)IC50: >10μM
p70S6KIC50: >10μM
PDGFRIC50: >10μM
PDK-1IC50: >10μM
PKBβIC50: >10μM
VEGFR1IC50: >10μM
AuroraAIC50: >10μM
c-AblIC50: >10μM
c-SrcIC50: >10μM
Chk1IC50: >10μM
EGFRIC50: >10μM
FGFR3IC50: >10μM
IRIC50: >10μM
JNK2IC50: >10μM
MAPK1IC50: >10μM
MEK1IC50: >10μM
MetIC50: >10μM
Solubility
Solubility (25C) * In vitro DMSO 10 mg/mL (26.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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