AT7867Catalog No. A10094

Quick Overview

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
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AT7867

Product Information
Catalog Num A10094
M. Wt 337.9
Formula C20H20ClN3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 857531-00-1
Synonyms AT-7867
Chemical Name 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
SMILES Code C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl

Biological activity
Introduction
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
Targets
Target Value
Akt2IC50: 17nM
PKAIC50: 20nM
Akt1IC50: 32nM
Akt3IC50: 47nM
p70S6KIC50: 85nM
RSK1IC50: >100nM
CDK2IC50: >1μM
GSK-3βIC50: >1μM
c-SrcIC50: >1μM
Chk1IC50: >1μM
EGFRIC50: >1μM
FGFR3IC50: >1μM
MEK1IC50: >1μM
PDK-1IC50: >1μM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
Tie-2IC50: >1μM
Solubility
Solubility (25C) * In vitro DMSO 68 mg/mL (201.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (14.79 mM)
In vivo 15% Captisol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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