AT9283Catalog No. A10095

Quick Overview

AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.
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AT9283

Product Information
Catalog Num A10095
M. Wt 381.4
Formula C19H23N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 896466-04-9
Synonyms N/A
Chemical Name 1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
SMILES Code C1CC1NC(=O)NC\2=CNN/C2=C\3/N=C4C=CC(=CC4=N3)CN5CCOCC5

Biological activity
Introduction
AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.
Targets
Target Value
JAK3IC50: 1.1nM
JAK2IC50: 1.2nM
AuroraAIC50: ~3.0nM
AuroraBIC50: ~3.0nM
Abl1(T315I)IC50: 4nM
GSK-3βIC50: 1nM-10nM
FGFR2IC50: 1-10nM
VEGFR3/FLT4IC50: 1nM-10nM
MerIC50: 1nM-10nM
RETIC50: 1nM-10nM
RSK2IC50: 1nM-10nM
RSK3IC50: 1nM-10nM
TYK2IC50: 1nM-10nM
YESIC50: 1nM-10nM
Abl(Q252H)IC50: 10nM-30nM
DRAK1IC50: 10nM-30nM
FGFR1IC50: 10nM-30nM
FGFR1(V561M)IC50: 10nM-30nM
FGFR2(N549H)IC50: 10nM-30nM
FGFR3IC50: 10nM-30nM
VEGFR1/FLT1IC50: 10nM-30nM
FLT3IC50: 10nM-30nM
PDGFRα(D842V)IC50: 10nM-30nM
PDK-1IC50: 10nM-30nM
PKCμIC50: 10nM-30nM
RSK4IC50: 10nM-30nM
Src(T341M)IC50: 10nM-30nM
VEGFR2IC50: 10nM-30nM
Solubility
Solubility (25C) * In vitro DMSO 76 mg/mL (199.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol 38 mg/mL (99.62 mM)
In vivo 15% Captisol 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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