Avasimibe (CI-1011)Catalog No. A10102

Quick Overview

Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor.
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Avasimibe (CI-1011)

Product Information
Catalog Num A10102
M. Wt 501.7
Formula C29H43NO4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 166518-60-1
Synonyms CI-1011, CI1011, PD 148515
Chemical Name [[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester] sulfamic acid
SMILES Code CC(C)C1=C(C(=CC=C1)C(C)C)OS(=O)(=O)NC(=O)CC2=C(C=C(C=C2C(C)C)C(C)C)C(C)C

Biological activity
Introduction
Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor.
Targets
CYP2C9 ACAT CYP1A2 CYP2C19
2.9 μM3.3 μM13.9 μM26.5 μM
Solubility
Solubility (25C) * In vitro DMSO 100 mg/mL (199.31 mM
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL (15.94 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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