AxitinibCatalog No. A10103

Quick Overview

Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).
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Axitinib

Product Information
Catalog Num A10103
M. Wt 386.5
Formula C22H18N4OS
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 319460-85-0
Synonyms AG 013736
Chemical Name N-Methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
SMILES Code CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)/C=C/C4=CC=CC=N4

Biological activity
Introduction
Axitinib is a small molecule tyrosine kinase inhibitor,which inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT (CD117).
Targets
Target Value
VEGFR1/FLT1IC50: 0.1nM
VEGFR2/Flk1IC50: 0.18nM
VEGFR2/KDRIC50: 0.2nM
VEGFR3IC50: 0.1nM-0.3nM
PDGFRβIC50: 1.6nM
KitIC50: 1.7nM
PDGFRαIC50: 5.0nM
CSF-1RIC50: 73nM
FLT3IC50: >1μM
Solubility
Solubility (25C) * In vitro DMSO 35 mg/mL heating (90.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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