AZD1152-HQPA (Barasertib)Catalog No. A10109

Quick Overview

AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases.
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AZD1152-HQPA (Barasertib)

Product Information
Catalog Num A10109
M. Wt 507.7
Formula C26H30FN7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 722544-51-6
Synonyms Barasertib
Chemical Name 5-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide
SMILES Code CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO

Biological activity
Introduction
AZD 1152-HQPA is a highly potent and selective inhibitor of Aurora B, with Ki values to be 0.36 (Aurora B) and 1369 nM (Aurora A) respectively and has a high specificity versus a panel of 50 other kinases.
Targets
Aurora B (Cell-free assay) Aurora A (Cell-free assay)
0.37 nM1368 nM
Solubility
Solubility (25C) * In vitro DMSO 102 mg/mL (200.96 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.91 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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