Olaparib (AZD2281)Catalog No. A10111

Quick Overview

Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
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Olaparib (AZD2281)

Product Information
Catalog Num A10111
M. Wt 434.5
Formula C24H23FN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 763113-22-0
Synonyms KU-0059436
Chemical Name 4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl) -4-fluorophenyl]methyl(2H)phthalazin-1-one
SMILES Code C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

Biological activity
Introduction
Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
Targets
PARP2 (Cell-free assay) PARP1 (Cell-free assay) Tankyrase-1 (Cell-free assay)
1 nM5 nM1.5 μM
Solubility
Solubility (25C) * In vitro DMSO 86 mg/mL (197.94 mM)
Water 0.002 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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