BIBW2992 (Afatinib)Catalog No. A10141

Quick Overview

BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
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BIBW2992 (Afatinib)

Product Information
Catalog Num A10141
M. Wt 485.9
Formula C24H25ClFN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 439081-18-2
Synonyms Tomtovok,Afatinib
Chemical Name N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide
SMILES Code CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[[email protected]]4CCOC4

Biological activity
Introduction
BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
Targets
EGFR (L858R) (Cell-free assay) EGFR (wt) (Cell-free assay) EGFR (L858R/T790M) (Cell-free assay) HER2 (Cell-free assay)
0.4 nM0.5 nM10 nM14 nM
Solubility
Solubility (25C) * In vitro DMSO 97 mg/mL (199.61 mM)
Water <1 mg/mL (<1 mM)
Ethanol 15 mg/mL (30.86 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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