BIX 02189 Catalog No. A10151

Quick Overview

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
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BIX 02189

Product Information
Catalog Num A10151
M. Wt 440.5
Formula C27H28N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1094614-85-3
Synonyms BIX02189, BIX-02189
Chemical Name 3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
SMILES Code CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)/C4=CC=CC=C4

Biological activity
Introduction
BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
Targets
Target Value
MEK5IC50: 1.5nM
ERK5IC50: 59nM
TGFβR1IC50: 580nM
MEK1IC50: >6.2μM
MEK2IC50: >6.2μM
ERK1IC50: >6.2μM
JNK2IC50: >6.2μM
EGFRIC50: >6.3μM
STK16IC50: >6.3μM
Solubility
Solubility (25C) * In vitro DMSO 60 mg/mL heating (136.19 mM)
Water <1 mg/mL (<1 mM)
Ethanol 80 mg/mL (181.59 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

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>>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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High Purity Kinase Inhibitors on Signaling Pathways

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