Quick Overview

Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling.
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Brivanib alaninate (BMS-582664)

Product Information
Catalog Num A10162
M. Wt 441.5
Formula C22H24FN5O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 649735-63-7
Synonyms BMS582664
Chemical Name (S)-(R)-1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-yl 2-aminopropanoate
SMILES Code CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[[email protected]@H](C)OC(=O)[[email protected]](C)N)C

Biological activity
Introduction
Brivanib alaninate (BMS-582664) is a dual tyrosine kinase inhibitor of VEGFR and FGFR signaling.
Targets
VEGFR2 Flk1 FGFR1 VEGFR1
25 nM89 nM148 nM380 nM
Solubility
Solubility (25C) * In vitro DMSO 88 mg/mL (199.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol 88 mg/mL (199.33 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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