PD184352 (CI-1040) Catalog No. A10212

Quick Overview

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
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PD184352 (CI-1040)

Product Information
Catalog Num A10212
M. Wt 478.7
Formula C17H14ClF2IN2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 212631-79-3
Synonyms CI-1040
Chemical Name 2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
SMILES Code C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl

Biological activity
Introduction
PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Targets
MEK1 (Cell-free assay) MEK2 (Cell-free assay)
17 nM17 nM
Solubility
Solubility (25C) * In vitro DMSO 96 mg/mL (200.55 mM)
Water <1 mg/mL (<1 mM)
Ethanol 14 mg/mL (29.24 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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