CYC116 (CYC-116)Catalog No. A10248

Quick Overview

Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.
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CYC116 (CYC-116)

Product Information
Catalog Num A10248
M. Wt 368.5
Formula C18H20N6OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 693228-63-6
Synonyms CYC-116
Chemical Name 4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine
SMILES Code CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4

Biological activity
Introduction
Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.
Targets
Target Value
AuroraAki: 8nM
AuroraBki: 9nM
VEGFR2ki: 44nM
FLT3ki: 44nM
CDK2/CyclinEki: 0.39μM
CDK9/CyclinTki: 0.48μM
p70S6Kki: 0.54μM
Srcki: 0.82μM
CDK4/CyclinDki: 1.09μM
LCKki: 2.8μM
CDK1/CyclinBki: >10μM
CDK7/CyclinHki: >10μM
Ablki: >10μM
Aktki: >10μM
CaMKIIki: >10μM
CK2ki: >10μM
ERK2ki: >10μM
GSK-3αki: >10μM
GSK-3βki: >10μM
PKAki: >10μM
PKCki: >10μM
SAPK2A(p38α)ki: >10μM
PLK1ki: >10μM
Solubility
Solubility (25C) * In vitro DMSO 24 mg/mL heating (65.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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