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Brivanib (BMS-540215)Catalog No. A10254

Quick Overview

Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM.
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Brivanib (BMS-540215)

Product Information
Catalog Num A10254
M. Wt 370.4
Formula C19H19FN4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 649735-46-6
Synonyms BMS540215
Chemical Name (R)-1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-ol
SMILES Code CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[[email protected]@H](C)O)C

Biological activity
Brivanib (BMS-540215) is a VEGFR -2 inhibitor with an IC50 of 25 nM and Ki of 26 nM.
Target Value
VEGFR2IC50: 25nM
Flk1IC50: 89nM
FGFR1IC50: 148nM
VEGFR1IC50: 380nM
EGFRIC50: >1.9μM
LCKIC50: >2.5μM
PDGFRβIC50: >6μM
PKCαIC50: >25μM
JAK3IC50: >50μM
Solubility (25C)* In vitro DMSO 74 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (8.09 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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