Cyt387 (Momelotinib)Catalog No. A10263

Quick Overview

CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.
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Cyt387 (Momelotinib)

Product Information
Catalog Num A10263
M. Wt 414.5
Formula C23H22N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1056634-68-4
Synonyms CYT 11387, Cyt-387
Chemical Name N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide
SMILES Code C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N

Biological activity
Introduction
CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively.
Targets
JAK1 JAK2 JAK3
11 nM18 nM155 nM
Solubility
Solubility (25C) * In vitro DMSO 83 mg/mL (200.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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High Purity Kinase Inhibitors on Signaling Pathways

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