Epothilone B (EPO906)Catalog No. A10360

Quick Overview

Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
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Epothilone B (EPO906)

Product Information
Catalog Num A10360
M. Wt 507.7
Formula C27H41NO6S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 152044-54-7
Synonyms Patupilone, Epothilone-B
Chemical Name (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16- pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)et henyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
SMILES Code C[[email protected]]1CCC[[email protected]@]2([[email protected]@H](O2)C[[email protected]](OC(=O)C[[email protected]@H](C(C(=O)[[email protected]@H]([[email protected]]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C

Biological activity
Introduction
Epothilone B is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.
Targets
Tubulin (Cell-free assay)
1.8 μM(EC0.01)
Solubility
Solubility (25C) * In vitro DMSO 102 mg/mL (200.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol 102 mg/mL (200.91 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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