Fasudil HCl (HA-1077)Catalog No. A10381

Quick Overview

Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
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Fasudil HCl (HA-1077)

Product Information
Catalog Num A10381
M. Wt 327.8
Formula C14H17N3O2S.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 105628-07-7
Synonyms AT-877
Chemical Name 1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride
SMILES Code C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl

Biological activity
Introduction
Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
Targets
ROCK2 (Cell-free assay) PKA (Cell-free assay) PKG (Cell-free assay) PKC (Cell-free assay) MLCK (Cell-free assay)
330 nM(Ki)1.6 μM(Ki)1.6 μM(Ki)3.3 μM(Ki)36 μM(Ki)
Solubility
Solubility (25C) * In vitro DMSO 5 mg/mL (15.25 mM)
Water 65 mg/mL (198.27 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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