Ispinesib (SB-715992)Catalog No. A10486

Quick Overview

Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.
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Ispinesib (SB-715992)

Product Information
Catalog Num A10486
M. Wt 517.1
Formula C30H33ClN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 336113-53-2
Synonyms Ispinesib mesylate,B-715992,CK 0238273
Chemical Name (R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide
SMILES Code CC1=CC=C(C=C1)C(=O)N(CCCN)[[email protected]@H](C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C

Biological activity
Introduction
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis.
Targets
KSP (HsEg5) (Cell-free assay)
1.7 nM(Ki app)
Solubility
Solubility (25C)* In vitro DMSO 103 mg/mL (199.2 mM)
Water <1 mg/mL (<1 mM)
Ethanol 103 mg/mL (199.2 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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