KU-55933Catalog No. A10506

Quick Overview

KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
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KU-55933

Product Information
Catalog Num A10506
M. Wt 395.5
Formula C21H17NO3S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 587871-26-9
Synonyms KU55933
Chemical Name 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
SMILES Code C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

Biological activity
Introduction
KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
Targets
Target Value
ATMIC50: 12.9nM
DNA-PKIC50: 2.5μM
mTORIC50: 9.3μM
PI3KIC50: 16.6μM
ATRIC50: >100μM
PI4KIC50: >100μM
Solubility
Solubility (25C) * In vitro DMSO 33 mg/mL (83.44 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO and 47.5% PEG300 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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