KW-2449Catalog No. A10508

Quick Overview

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.
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KW-2449

Product Information
Catalog Num A10508
M. Wt 332.4
Formula

C20H20N4O

Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1000669-72-6
Synonyms KW 2449, KW2449
Chemical Name [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
SMILES Code C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43

Biological activity
Introduction
KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.
Targets
Target Value
FLT3(D835Y)IC50: 1nM
Abl(T315I)IC50: 4nM
FLT3IC50: 6.6nM
AblIC50: 14nM
FGFR1IC50: 36nM
AuroraAIC50: 48nM
JAK2IC50: 150nM
KitIC50: 300nM
SrcIC50: 400nM
PDGFRαIC50: 1.7μM
Solubility
Solubility (25C) * In vitro DMSO 67 mg/mL (201.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol 67 mg/mL (201.56 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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>>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


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High Purity Kinase Inhibitors on Signaling Pathways

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