LBH589 (Panobinostat)Catalog No. A10518

Quick Overview

LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
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LBH589 (Panobinostat)

Product Information
Catalog Num A10518
M. Wt 349.4
Formula C21H23N3O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 404950-80-7
Synonyms NVP-LBH589, LBH-589
Chemical Name (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide
SMILES Code CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO

Biological activity
Introduction
LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
Targets
HDAC (MOLT-4 cells) HDAC (Reh cells)
5 nM20 nM
Solubility
Solubility (25C) * In vitro DMSO 69 mg/mL (197.46 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% DMSO, 2% Tween 80, 48% PEG 300 5
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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