LetrozoleCatalog No. A10523

Quick Overview

Letrozole is an Aromatase inhibitor. CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1–3 μg/kg p.o.)
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Letrozole

Product Information
Catalog Num A10523
M. Wt 285.3
Formula C17H11N5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 112809-51-5
Synonyms CGS 20267, Femara, Piroxicam
Chemical Name 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
SMILES Code C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

Biological activity
Introduction
Letrozole is an Aromatase inhibitor. CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1–3 μg/kg p.o.)
Targets
Aromatase (Cell-free assay)
0.07 nM-20 nM
Solubility
Solubility (25C) * In vitro DMSO 57 mg/mL (199.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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High Purity Kinase Inhibitors on Signaling Pathways

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