LY2140023 (LY404039)Catalog No. A10544

Quick Overview

LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results.
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LY2140023 (LY404039)

Product Information
Catalog Num A10544
M. Wt 235.2
Formula C7H9NO6S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 635318-11-5
Synonyms LY-404039, LY-2140023
Chemical Name (1R,4S,5S,6S)-4-Amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
SMILES Code C1[[email protected]]([[email protected]@H]2[[email protected]]([[email protected]@H]2S1(=O)=O)C(=O)O)(C(=O)O)N

Biological activity
Introduction
LY-404039 is a drug used in scientific research that acts as a selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. It has anxiolytic and antipsychotic effects in animal studies, but without causing sedation. Early human trials using a prodrug form of LY-404,039 called LY-214,0023 have also given encouraging results.
Targets
Rat neurons expressing native mGlu2/3 Recombinant human mGlu3 Recombinant human mGlu2
88 nM(Ki)92 nM(Ki)149 nM(Ki)
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