MLN2238Catalog No. A10600

Quick Overview

MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.
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MLN2238

Product Information
Catalog Num A10600
M. Wt 361.0
Formula C14H19BCl2N2O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1072833-77-2
Synonyms MLN 2238, MLN-2238
Chemical Name (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
SMILES Code B([[email protected]](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O

Biological activity
Introduction
MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.
Targets
20S proteasome (Cell-free assay) 20S proteasome (Cell-free assay)
0.93 nM(Ki)3.4 nM
Solubility
Solubility (25C) * In vitro DMSO 72 mg/mL (199.42 mM)
Water <1 mg/mL (<1 mM)
Ethanol 9 mg/mL (24.92 mM)
In vivo 0.5% hydroxyethyl cellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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