NVP-BHG712Catalog No. A10661

Quick Overview

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
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NVP-BHG712

Product Information
Catalog Num A10661
M. Wt 503.5
Formula C26H20F3N7O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 940310-85-0
Synonyms NVPBHG712
Chemical Name 4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide trifluoroacetate
SMILES Code CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5

Biological activity
Introduction
NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
Targets
Target Value
EphB4ED5025nM
C-RafIC50: 0.395μM
c-SrcIC50: 1.266μM
c-AblIC50: 1.667μM
Tie-2IC50: >10μM
AxlIC50: >10μM
HER1IC50: >10μM
PKAIC50: >10μM
CDK1IC50: >10μM
PKBIC50: >10μM
PDK-1IC50: >10μM
FGFR3IC50: >10μM
c-MetIC50: >10μM
Solubility
Solubility (25C) * In vitro DMSO 101 mg/mL (200.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.95 mM)
In vivo NMP/polyethylene glycol 300 (10/90, v/v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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