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PD173074Catalog No. A10703

Quick Overview

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.
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Product Information
Catalog Num A10703
M. Wt 523.7
Formula C28H41N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 219580-11-7
Synonyms PD-173074
Chemical Name N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

Biological activity
PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.
Target Value
FGFR1IC50: ~25nM
VEGFR2IC50: 100nM-200nM
c-SrcIC50: 19.8μM
EGFRIC50: >50μM
Insulin ReceptorIC50: >50μM
MEKIC50: >50μM
PKCIC50: >50μM
Solubility (25C)* In vitro DMSO 100 mg/mL (190.95 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (190.95 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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