Danusertib (PHA-739358)Catalog No. A10715

Quick Overview

Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2
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Danusertib (PHA-739358)

Product Information
Catalog Num A10715
M. Wt 474.6
Formula C26H30N6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 827318-97-8
Synonyms PHA739358
Chemical Name N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
SMILES Code CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)[[email protected]@H](C5=CC=CC=C5)OC

Biological activity
Introduction
Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. Phase 2
Targets
Target Value
AuroraAIC50: 13nM
AblIC50: 25nM
RETIC50: 31nM
TrkAIC50: 31nM
FGFR1IC50: 47nM
AuroraCIC50: 61nM
AuroraBIC50: 79nM
Solubility
Solubility (25C) * In vitro DMSO 95 mg/mL (200.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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