PIK-75Catalog No. A10729

Quick Overview

PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.
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PIK-75

Product Information
Catalog Num A10729
M. Wt 488.7
Formula C16H14BrN5O4S.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 372196-77-5
Synonyms PIK75
Chemical Name 2-​methyl-​5-​nitro-​2-​[(6-​bromoimidazo[1,​2-​a]pyridin-​3-​yl)methylene]-​1-​methylhydrazide-​benzenesulfonic acid
SMILES Code CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl

Biological activity
Introduction
PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.
Targets
DNA-PK (Cell-free assay) p110α (Cell-free assay) p110γ (Cell-free assay) p110δ (Cell-free assay) p110β (Cell-free assay)
2 nM5.8 nM76 nM0.51 μM1.3 μM
Solubility
Solubility (25C)* In vitro DMSO 3 mg/mL (6.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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