PLX4032 (Vemurafenib)Catalog No. A10739

Quick Overview

PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
Products are for laboratory research use only. Not for human use. We do not sell to patients.

PLX4032 (Vemurafenib)

Product Information
Catalog Num A10739
M. Wt 489.9
Formula C23H18ClF2N3O3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 918504-65-1
Synonyms RG7204,RO5185426,Zelboraf, PLX-4032
Chemical Name N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide
SMILES Code CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F

Biological activity
Introduction
PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
Targets
Target Value
SRMSIC50: 18nM
ACK1IC50: 19nM
B-Raf(V600E)IC50: 31nM
C-RafIC50: 48nM
MAP4K5(KHS1)IC50: 51nM
FGRIC50: 63nM
B-RafIC50: 100nM
LCKIC50: 183nM
BRKIC50: 213nM
NEK11IC50: 317nM
BLKIC50: 547nM
LynBIC50: 599nM
YES1IC50: 604nM
WNK3IC50: 877nM
MNK2IC50: 1.717μM
FRK(PTK5)IC50: 1.884μM
CSKIC50: 2.339μM
SrcIC50: 2.389μM
Solubility
Solubility (25C) * In vitro DMSO 98 mg/mL (200.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

>>This offer is only valid for products purchased directly from Adooq and its authorized distributors.

>>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


Website: www.adooq.com
Order: [email protected]
Phone:
(866)930-6790 (US & Canada)
+1-323-389-9269 (Outside of US & CAN)
Fax:
(866)333-9607 (US & Canada)
+1-323-606-8156 (Outside of US & CAN)
Support:
[email protected]

High Purity Kinase Inhibitors on Signaling Pathways

Copyright© 2006-2017 Adooq BioScience LLC, All Rights Reserved.
4000 Barranca Parkway, Suite 250, Irvine, CA 92604 USA. Tel: 855-930-6790