Roscovitine (Seliciclib)Catalog No. A10806

Quick Overview

Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.
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Roscovitine (Seliciclib)

Product Information
Catalog Num A10806
M. Wt 354.5
Formula C19H26N6O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 186692-46-6
Synonyms CYC202, Seliciclib
Chemical Name 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
SMILES Code CC[[email protected]](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C

Biological activity
Introduction
Roscovitine (Seliciclib) is a CDK inhibitor that preferentially inhibit multiple enzyme targets including CDK2, CDK7 and CDK9.
Targets
Target Value
CDK5/p35IC50: 0.16μM
Cdc2/CyclinBIC50: 0.65μM
CDK2/CyclinAIC50: 0.7μM
CDK2/CyclinEIC50: 0.7μM
ERK2IC50: 14μM
GST-ERK1IC50: 30μM
ERK1IC50: 34μM
CDK4/CyclinD1IC50: >100μM
CDK6/CyclinD3IC50: >100μM
PKCαIC50: >100μM
PKCβ1IC50: >100μM
PKCβ2IC50: >100μM
PKCγIC50: 100μM
PKCεIC50: >100μM
PKCηIC50: >100μM
c-SrcIC50: 250μM
PKCδIC50: >1000μM
PKCζIC50: >1000μM
v-AblIC50: >1000μM
Solubility
Solubility (25C) * In vitro DMSO 71 mg/mL (200.31 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (16.92 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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