SB 216763Catalog No. A10825

Quick Overview

SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).
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SB 216763

Product Information
Catalog Num A10825
M. Wt 371.2
Formula C19H12Cl2N2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 280744-09-4
Synonyms SB-216763, SB216763
Chemical Name 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
SMILES Code CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl

Biological activity
Introduction
SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).
Targets
GSK-3α GSK-3β
34.3 nM~34.3 nM
Solubility
Solubility (25C) * In vitro DMSO 23 mg/mL (61.95 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 11 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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