SGI-1776 (free base)Catalog No. A10838

Quick Overview

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
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SGI-1776 (free base)

Product Information
Catalog Num A10838
M. Wt 405.4
Formula C20H22F3N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1025065-69-3
Synonyms SGI1776
Chemical Name N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine sulfate
SMILES Code CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2

Biological activity
Introduction
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
Solubility
Solubility (25C) * In vitro DMSO 81 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 81 mg/mL (199.79 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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