SGX-523 Catalog No. A10839

Quick Overview

SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.
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SGX-523

Product Information
Catalog Num A10839
M. Wt 359.4
Formula C18H13N7S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1022150-57-7
Synonyms SGX523
Chemical Name 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
SMILES Code CN1C=C(C=N1)C2=NN3C(=NN=C3SC4=CC5=C(C=C4)N=CC=C5)C=C2

Biological activity
Introduction
SGX-523 is an orally bioavailable small molecule, specifically binds to c-Met protein, or HGFR, preventing binding of HGF and disrupting the MET signaling pathway.
Targets
Target Value
c-MetIC50: 4nM
B-Raf(V599E)IC50: >7μM
C-RafIC50: >7μM
AblIC50: >7μM
p38αIC50: >7μM
Abl1(Y253F)IC50: >7μM
Solubility
Solubility (25C) * In vitro DMSO 2 mg/mL (5.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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