StaurosporineCatalog No. A10864

Quick Overview

Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.
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Staurosporine

Product Information
Catalog Num A10864
M. Wt 466.5
Formula C28H26N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 62996-74-1
Synonyms AM-2282, STS
Chemical Name (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
SMILES Code C[[email protected]@]12[[email protected]@H]([[email protected]@H](C[[email protected]@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Biological activity
Introduction
Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase.
Targets
Target Value
PKCαIC50: 2nM
c-FgrIC50: 2nM
phosphorylasekinaseIC50: 3nM
PKCηIC50: 4nM
PKCγIC50: 5nM
S6kinaseIC50: 5nM
v-SrcIC50: 6nM
Cdc2IC50: 9nM
Cdc2IC50: 9nM
PKAIC50: 15nM
SykIC50: 16nM
PKGIC50: 18nM
PKCδIC50: 20nM
CaMKIIIC50: 20nM
LynIC50: 20nM
MLCKIC50: 21nM
PKCεIC50: 73nM
PKCζIC50: 1086nM
Solubility
Solubility (25C)* In vitro DMSO 4 mg/mL (8.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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