SU11274Catalog No. A10869

Quick Overview

SU11274 is a Met tyrosine kinase inhibitor.
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SU11274

Product Information
Catalog Num A10869
M. Wt 568.1
Formula C28H30CIN5O4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 658084-23-2
Synonyms SU-11274, PKI-SU11274
Chemical Name (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
SMILES Code CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)/C=C\3/C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O

Biological activity
Introduction
SU11274 is a Met tyrosine kinase inhibitor.
Targets
Target Value
MetIC50: 0.01μM
Flk1IC50: 1.25μM
RONIC50: 4.0μM
FGFR1IC50: 8.5μM
CDK2IC50: >10μM
PDGFRβIC50: >20μM
EGFRIC50: >100μM
Solubility
Solubility (25C) * In vitro DMSO 92 mg/mL (161.94 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (3.52 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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