Tandutinib (MLN518)Catalog No. A10887

Quick Overview

Tandutinib (MLN518) inhibits the autophosphorylation of FLT3, c-KIT and PDGF receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.
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Tandutinib (MLN518)

Product Information
Catalog Num A10887
M. Wt 562.7
Formula C31H42N6O4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 387867-13-2
Synonyms MLN-518, CT53518
Chemical Name 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide; (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide
SMILES Code CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5

Biological activity
Introduction
Tandutinib (MLN518) inhibits the autophosphorylation of FLT3, c-KIT and PDGF receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.
Targets
Target Value
c-KitIC50: 0.17μM
PDGFRβIC50: 0.20μM
FLT3IC50: 0.22μM
CSF-1RIC50: 3.43μM
SrcIC50: 30μM
AblIC50: >30μM
PKCIC50: >30μM
PKAIC50: >30μM
MEK1IC50: >30μM
MKK4IC50: >30μM
MKK6IC50: >30μM
ERK2IC50: >30μM
p38IC50: >30μM
KDRIC50: >30μM
EGFRIC50: >30μM
FGFRIC50: >30μM
Insulin ReceptorIC50: >30μM
Solubility
Solubility (25C) * In vitro DMSO 5 mg/mL (8.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (10.66 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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