Vatalanib (PTK787) 2HClCatalog No. A10967

Quick Overview

Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2.
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Vatalanib (PTK787) 2HCl

Product Information
Catalog Num A10967
M. Wt 419.7
Formula C20H17Cl3N4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 212141-54-3
Synonyms Vatalanib,PTK787,PTK/ZK
Chemical Name N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride
SMILES Code C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl

Biological activity
Introduction
Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2.
Targets
Target Value
VEGFR2/KDRIC50: 37nM
VEGFR1/FLT1IC50: 77nM
VEGFR2/Flk1IC50: 270nM
PDGFRβIC50: 580nM
VEGFR3/FLT4IC50: 660nM
c-KitIC50: 730nM
c-FmsIC50: 1.4μM
Solubility
Solubility (25C)* In vitro DMSO 85 mg/mL (202.51 mM)
Water 10 mg/mL (23.82 mM)
Ethanol 6 mg/mL (14.29 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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