VX-222Catalog No. A10980

Quick Overview

VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
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VX-222

Product Information
Catalog Num A10980
M. Wt 445.6
Formula C25H35NO4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1026785-59-0
Synonyms VCH222, VX222
Chemical Name 5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid
SMILES Code CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O

Biological activity
Introduction
VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
Targets
HCV NS5B 1a HCV NS5B 1b
0.94 μM1.2 μM
Solubility
Solubility (25C) * In vitro DMSO 89 mg/mL (199.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol 89 mg/mL (199.72 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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