WZ3146Catalog No. A10990

Quick Overview

WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.
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WZ3146

Product Information
Catalog Num A10990
M. Wt 465.0
Formula C24H25ClN6O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1214265-56-1
Synonyms WZ-3146
Chemical Name N-[3-[[5-Chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
SMILES Code CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

Biological activity
Introduction
WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less potent against wild-type EGFR kinase.
Targets
EGFR (L858R) EGFR (E746_A750) EGFR (L858R/T790M) EGFR (E746_A750/T790M)
2 nM2 nM5 nM14 nM
Solubility
Solubility (25C)* In vitro DMSO 93 mg/mL (200.02 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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