Foretinib (GSK1363089, XL880)Catalog No. A10998

Quick Overview

Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.
Products are for laboratory research use only. Not for human use. We do not sell to patients.

Foretinib (GSK1363089, XL880)

Product Information
Catalog Num A10998
M. Wt 632.7
Formula C34H34F2N4O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 849217-64-7
Synonyms GSK089, EXEL-2880
Chemical Name N1’-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
SMILES Code COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F

Biological activity
Introduction
Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.
Targets
Target Value
MetIC50: 0.4nM
KDRIC50: 0.86nM
Tie-2IC50: 1.1nM
VEGFR3/FLT4IC50: 2.8nM
RONIC50: 3nM
FLT3IC50: 3.6nM
PDGFRαIC50: 3.6nM
KitIC50: 6.7nM
VEGFR1/FLT1IC50: 6.8nM
PDGFRβIC50: 9.6nM
FGFR1IC50: 660nM
EGFRIC50: 2.99μM
Solubility
Solubility (25C) * In vitro DMSO 127 mg/mL (200.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

>>This offer is only valid for products purchased directly from Adooq and its authorized distributors.

>>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


Website: www.adooq.com
Order: [email protected]
Phone:
(866)930-6790 (US & Canada)
+1-323-389-9269 (Outside of US & CAN)
Fax:
(866)333-9607 (US & Canada)
+1-323-606-8156 (Outside of US & CAN)
Support:
[email protected]

High Purity Kinase Inhibitors on Signaling Pathways

Copyright© 2006-2017 Adooq BioScience LLC, All Rights Reserved.
4000 Barranca Parkway, Suite 250, Irvine, CA 92604 USA. Tel: 855-930-6790