Zibotentan (ZD4054)Catalog No. A11006

Quick Overview

Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).
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Zibotentan (ZD4054)

Product Information
Catalog Num A11006
M. Wt 424.4
Formula C19H16N6O4S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 186497-07-4
Synonyms ZD-4054
Chemical Name N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide
SMILES Code CC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4

Biological activity
Introduction
Zibotentan (ZD4054)is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM).
Targets
ET-A
21 nM
Solubility
Solubility (25C) * In vitro DMSO 24 mg/mL (56.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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