PCI-32765Catalog No. A11020

Quick Overview

PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
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PCI-32765

Product Information
Catalog Num A11020
M. Wt 440.5
Formula C25H24N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 936563-96-1
Synonyms Ibrutinib
Chemical Name 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
SMILES Code C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N

Biological activity
Introduction
PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
Targets
Target Value
BTKIC50: 0.5nM
BLKIC50: 0.5nM
BmxIC50: 0.8nM
CSKIC50: 2.3nM
FGRIC50: 2.3nM
BRKIC50: 3.3nM
HckIC50: 3.7nM
EGFRIC50: 5.6nM
YESIC50: 6.5nM
ErbB2IC50: 9.4nM
ITKIC50: 10.7nM
JAK3IC50: 16.1nM
FRKIC50: 29.2nM
LCKIC50: 33.2nM
RETIC50: 36.5nM
FLT3IC50: 73nM
TECIC50: 78nM
AblIC50: 86nM
FynIC50: 96nM
RIPK2IC50: 152nM
c-SrcIC50: 171nM
LynIC50: 200nM
PDGFRαIC50: 718nM
FmsIC50: 5.545μM
FERIC50: 8.07μM
JAK1IC50: >10μM
JAK2IC50: >10μM
NEK2IC50: >10μM
p38IC50: >10μM
PI3KIC50: >10μM
PLK1IC50: >10μM
RSK1IC50: >10μM
SykIC50: >10μM
Solubility
Solubility (25C) * In vitro DMSO 88 mg/mL (199.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 12 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Reference:

 

[1]. Pan, Z; Scheerens, H; Li, SJ; Schultz, BE; Sprengeler, PA; Burrill, LC; Mendonca, RV; Sweeney, MD; Scott, KC; Grothaus, Paul G.; Jeffery, Douglas A.; Spoerke, Jill M.; Honigberg, Lee A.; Young, Peter R.; Dalrymple, Stacie A.; Palmer, James T. (2007). “Discovery of selective irreversible inhibitors for Bruton’s tyrosine kinase”. ChemMedChem 2 (1): 58–61.

[2]. Honigberg, LA; Smith, AM; Sirisawad, M; Verner, E; Loury, D; Chang, B; Li, S; Pan, Z; Thamm, DH; Miller, RA; Buggy, JJ (2010). “The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy”. Proceedings of the National Academy of Sciences of the United States of America 107 (29): 13075–80.

[3]. Ponader S, Chen SS, Buggy JJ, Balakrishnan K, Gandhi V, Wierda WG, Keating MJ, O’Brien S, Chiorazzi N, Burger JA (2012). The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo 119. Blood. pp. 1182–1189.

 

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