GDC-0980 (Apitolisib, RG7422)Catalog No. A11023

Quick Overview

GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.
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GDC-0980 (Apitolisib, RG7422)

Product Information
Catalog Num A11023
M. Wt 498.6
Formula C23H30N8O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1032754-93-0
Synonyms GDC0980
Chemical Name (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
SMILES Code CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[[email protected]](C)O

Biological activity
Introduction
GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.
Targets
p110α (Cell-free assay) p110δ (Cell-free assay) p110γ (Cell-free assay) mTOR (Cell-free assay) p110β (Cell-free assay)
5 nM7 nM14 nM17 nM(Ki app)27 nM
Solubility
Solubility (25C) * In vitro DMSO 20 mg/mL (40.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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